Helper T Cell Polarizing Through Dendritic Cells.
- Author:
Manyong HAN
1
Author Information
1. Department of Pediatrics, College of Medicine, Pochon CHA University, Sungnam, Korea. drmesh@cha.ac.kr
- Publication Type:Review
- Keywords:
Toll like receptor;
Plasmacytoid dendritic cell;
Myeloid dendritic cell;
Th1/Th2 deviation
- MeSH:
Asthma;
Comprehension;
Dendritic Cells*;
Humans;
Hypersensitivity;
Toll-Like Receptors
- From:Korean Journal of Pediatrics
2005;48(1):6-12
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In the last few years, a spectrum of dendritic cells(DCs), including toll like receptors(TLRs), might play a critical role in regulating allergy and asthma. DC plays a central role in initiating immune responses, linking innate and adaptive responses to pathogen. Human peripheral blood has three non- overlapping dendritic subset that expressed various 11 TLRs. These dendritic subsets and TLR contribute significant polarizing influences on T helper differentiation, but how this comes about is less clear. A better understanding of DC immunobiology may lead to the comprehension of allergy pathophysiology to prevent early stage allergic march.
