Non-motor symptoms in Parkinson' s disease: three years follow-up
10.3760/cma.j.issn.1006-7876.2012.06.002
- VernacularTitle:帕金森病患者的非运动症状三年随访
- Author:
Jing GAN
;
Xiaoyu REN
;
Yarong WEI
;
Mingzhu ZHOU
;
Haiyang HE
;
Lixia LU
;
Jiaying WU
;
Wei CHEN
;
Ying WAN
;
Zhenguo LIU
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Nonmotor symptom;
Follow-up;
Quality of life
- From:
Chinese Journal of Neurology
2012;45(6):364-368
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the development,progression and change of nonmotor symptoms in patients with Parkinson' s disease and its impact on patients' quality of life.Methods Eighty-seven consecutive patients with idiopathic Parkinson' s disease were studied.Parkinsonian status was assessed at baseline and 3 years follow-up using Unified Parkinson' s Disease Rating Scale (UPDRS) part Ⅲ & Ⅳ,Nonmotor Symptoms Questionnaire (NMSQuset),Parkinson-related quality of life (PDQ) scales.Paired ttest,Chi-square test,Spearman rank order correlation and hierarchical regression of the major statistical procedures were employed.Results At 3 years follow-up,compared to baseline,the UPDRS Ⅲ score (22.21 ±11.31 vs 30.49± 11.68),UPDRS Ⅳ score(1.00±1.54 vs 2.94±3.12),NMS score (7.98±3.96 vs 12.35 ± 5.12) and PDQ score (28.11 ± 22.88 vs 36.65 ± 26.95) were significantly higher ( t =- 5.54,- 5.75,- 6.46,- 5.29,all P =0.000,respectively).The aggravation of motor and nonmotor symptoms caused the decline of quality of life.The prevalence of constipation,problem of remembenng thing,nocturia ranked tops,and depression,and anxiety were still in the middle,compared with baseline.The prevalence of pains,sweating,dribbling,sense of incomplete emptying etc were significantly increased during the follow-up,△R2 were 21.6% and 23.4% respectively,resulting in the deterioration of quality of life.Conclusions PD nonmotor symptoms appear from the early stage.The motor and nonmotor symptoms aggravate over time.