Penicillin Resistant Distribution and in-vitro Susceptibility of Oral Antibiotics against Streptococcus pneumoniae, isolated from Pediatric Patients with Community- Acquired Respiratory Infections in Korea.
- Author:
Jin Han KANG
1
;
Sun Mi KIM
;
Jong Hyun KIM
;
Hur Jae KYUN
;
Kyung Yil LEE
;
Young Ku SHIN
;
Su Eun PARK
;
Sang Hyuk MA
;
Young Jin HONG
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. kjhan@olmh,cuk.ac.kr
- Publication Type:Original Article
- Keywords:
Respiratory tract infection;
Community-acquired infections;
Streptococcus pneumoniae;
Penicillin resistance;
Antibiotic susceptibility
- MeSH:
Amoxicillin;
Anti-Bacterial Agents*;
Anti-Infective Agents;
Cefaclor;
Clavulanic Acid;
Community-Acquired Infections;
Drug Resistance, Microbial;
Hope;
Humans;
Korea*;
Otitis;
Penicillin Resistance;
Penicillins*;
Pneumonia;
Respiratory Tract Infections*;
Sinusitis;
Streptococcus pneumoniae*;
Streptococcus*
- From:Korean Journal of Pediatrics
2005;48(1):40-47
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: S. pneumoniae is one of major pathogens of community-acquired respiratory infections. The rate of antibiotic resistance to this organism has increased, and resistance to multiple antimicrobial agents in a single strain of S. pneumoniae may compromise the efficacy of empiric antimicrobial treatment commonly used for respiratory infections. We did this study to find out the penicillin resistant distributions and oral antibiotics susceptibility patterns against S. pneumoniae, isolated from pediatric patients with community-acquired respiratory infections in Korea. METHODS: One hundred fifty six pneumococcal isolates obtained from pediatric patients with community-acquired respiratory infections such as acute otitis media(AOM), sinusitis and pneumonia between May 2000 to June 2003. And MICs of penicillin and oral antibiotics(amoxicillin, amoxicillin- clavulanate, cefaclor) were performed by broth microdilution methods according to the NCCLS(2003a). RESULTS: Seventy eight percent of the isolates were resistant to penicillin. The isolates, collected from AOM patients showed the highest penicillin resistance(92.7%). The resistant rates of amoxicillin (16.7%) and amoxicillin-clavulanate(9.6%), based on susceptibility breakpoints established by the NCCLS, were markedly lower than these of penicillin. But, the resistant rate of cefaclor was very high, above 95%. CONCLUSION: We concluded that pneumococci isolated from study cases may be one of the world's highest penicillin resistant rates. But, amoxicillin and amoxicillin-clavulanate can be used as a first- line antibiotics. Finally, we hope that a continuous surveillance study to monitor resistant patterns of pneumococcal respiratory infections will be needed for the standard guidelines of empiric antibiotic treatment.
