Relationship of Survivin and Caspase-3 protein in ovarian serous tumors and their clinical signifficance

VernacularTitle:卵巢浆液性肿瘤中Survivin和Caspase-3蛋白表达的相关性及其临床意义
Author: Dongmei DU ; Jinrui HE
Publication Type:Journal Article
Keywords: Ovarian neoplasms; Survivin; Caspase-3; Flow cytometry
From: Cancer Research and Clinic 2012;24(5):308-310
CountryChina
Language:Chinese
Abstract: Objective To investgate the expression of Survivin and Caspase-3 in primary ovarian carcinoma, and to explore their relationship. Methods The expression of Survivin and Caspase-3 was detected by flow cytometry (FCM) . Results FCM showed that the expression of Survivin in ovarian serous carcinoma was higher than that in serous cystadenoma and normal ovarian tissues (F=19.80;P=0.00) and correlated with the clinical stage( t=2.882,P=0.009).The expression of Caspase-3 in ovarian serous carcinoma was higher than that in serous cystadenoma and normal ovarian tissues (F=16.32,P=0.00)and has no correlativity with clinical stage,histological grade,and lymph metastasis(P＞0.05).Survivin expression was negatively correlated with Caspase-3 expression in ovarian serous tumors (r=0.43,P=0.029).Conclusion Survivin was negatively correlated with Caspase-3 in ovarian serous tumors.Combination of detecting the two protein expressions might be valuable in diagnosis and determining the malignant degree in ovarian serous carcinoma.