The history and development of quantitative analysis of hemoglobin
10.3760/cma.j.issn.1009-9158.2012.05.004
- VernacularTitle:血红蛋白定量分析技术的历史和发展
- Author:
Ping CHEN
- Publication Type:Journal Article
- Keywords:
Hemoglobinometry;
Thalassemia;
Quality control
- From:
Chinese Journal of Laboratory Medicine
2012;35(5):399-403
- CountryChina
- Language:Chinese
-
Abstract:
Thalassemias are a group of inherited disease which is caused by globin gene defects.Identification and quantification of hemoglobin play a very important role for the screening and diagnosis of thalassemia,especially the quantitative analysis of Hb A2 and Hb F.Through past 60 years,the methods for Hemoglobin analysis have been developed from starch gel electrophoresis,paper electrophoresis,cellulose acetate electrophoresis,agarose gel electrophoresis,column chromatography,high-performance liquid chromatography till capillary electrophoresis,Its development closely associates with the research on thalassemia.No matter what kind of methods is chosen,quality control is very important.
