Endoscopic submucosal dissection for colorectal laterally spreading tumors
10.3760/cma.j.issn.1007-5232.2012.05.005
- VernacularTitle:内镜黏膜下剥离术治疗大肠侧向发育型肿瘤的探讨
- Author:
Wei GONG
;
Side LIU
;
Fachao ZHI
;
Yang BAI
;
Dan ZHOU
;
Ying HUANG
;
Bo JIANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Laterally spreading tumor;
Endoscopic submucosal dissec
- From:
Chinese Journal of Digestive Endoscopy
2012;29(5):255-258
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the efficacy and safety of endoscopic submucosal dissection (ESD) for the treatment of laterally spreading tumors (LST).MethodsESD was applied to remove 32 colorectal LSTs larger than 2 cm.The characteristics of the tumors and clinical results including en bloc resection rate,procedure time,complication and recttrrence rates were retrospectively evaluated.Results The lesions ranged from 2.5 cm to 8.0 cm,with a mean diameter of 4.1 ± 2.1 cm.En bloc resection wasachieved in 29 patients (90.6％ ) with a mean operation time of 75.7 ±66.0 min.Immediate arerial bleeding occurred in 5 ( 15.6％ ) cases but was stopped successfully by clips or coagulations.Late bleeding occurred in 2 ( 6.2％ ) and perforations in 3 (9.4％ ),which were closed successfully by clips without surgery.Pathological diagnosis revealed low-grade intraepithelial dysplasia in 19 (59.4％ ),high-grade intraepithelial dysplasia in 6 ( 18.8％ ),and carcinomas in 7 (21.9％).The lesions were restricted in mucosal layer in 25 (78.1％ ),infiltrating into sm1 layer in 5 ( 15.6％ ) and sm2 layer in 2 (6.2％ ),and the later 2 were referred to surgery.Twenty patients were followed up for 3-12 months,and no local recurrence was found..ConclusionESD was an effective and safe therapy for colorectal LST larger than 2 cm.
