Heart-type fatty acid binding protein in the early diagnosis of myocardial infarction after off-pump coronary artery bypass
10.3760/cma.j.issn.1001-4497.2012.05.011
- VernacularTitle:心肌型脂肪酸结合蛋白早期快速诊断OPCAB术后心肌梗死
- Author:
Dongmei MENG
;
Peijun LI
;
Zihou LIU
;
Jie LI
;
Jing SUN
;
Zhigang GUO
;
Jianshi LIU
- Publication Type:Journal Article
- Keywords:
Heart-type fatty acid-binding protein;
Coronary artery bypass,off-pump;
Myocardial infarction;
ROC curve;
Early diagnosis
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2012;28(5):298-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the early diagnostic value of Heart-type fatty acid-binding protein(H-FABP) for myocardial infarction in patients post off-pump coronary artery bypass (OPCAB).Methods Between March 2009 and July 2009,59 patients had been undergone OPCAB for the first time.They were divided into 3 groups (normal group,myocardial injury group and myocardial infarction group) by myocardial-bound creatiue kinase (CK-MB) 、cardiac troponio Ⅰ (cTnI) 、electrocardiogram (ECG) and echocardiogram.Serial blood samples were taken during perioperation to quantify blood levels of H-FABP,CK-MB,cTnI.Results The average H-FABP value for the patients in the myocardial infarction group is higher than the others ( P ＜ 0.01 ).H-FABP reached the peak valve at 2 hours and decreased at 4 hours after the patients arrived at ICU.H-FABP got back to the baseline one day postoperation.Receiver operating characteristic curves( ROC curve) demonstrated that H-FABP had greater diagnostic ability of myocardial infarction postoperation with area under the curve at the time of arriving at ICU ( 0.900,95％ CI 0.818 -0.981 )and 2 hours later (0.832,95％ CI 0.718 -0.946).At the time of arriving at ICU,sensitivity of H-FABP for diagnosis was 90.9％ and specificity was 77.1％.At the point of 2 hours later,sensitivity was 72.7％ and specificity was 75.0％.Conclusion The H-FABP seems to be an excellent early biomarker of cardiac necrosis after OPCAB.
