Efficacy and safety of low-protein diet combined with α-keto acids on chronic hepatitis B patients complicated with chronic kidney diseases
10.3760/cma.j.issn.1001-7097.2012.04.008
- VernacularTitle:α-酮酸联合低蛋白饮食治疗慢性乙型肝炎并发慢性肾脏病的疗效和安全性
- Author:
Jialin LI
;
Zanzhe YU
;
Shan MOU
;
Qin WANG
;
Beili SHI
;
Zhaohui NI
- Publication Type:Journal Article
- Keywords:
α-Keto acids;
Diet protein restricted;
Hepatitis B,chronic;
Renal insufficiency,chronic
- From:
Chinese Journal of Nephrology
2012;28(4):286-290
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of short-term restriction of dietary protein intake (DPI) supplemented with α-keto acids on chronic hepatitis B patients complicated with chronic kidney diseases (CKD). Methods A prospective randomized controlled trial was carried out.Seventeen chronic hepatitis B patients with CKD were randomized to either low DPI with α-keto acid-supplemented (sLP) or low DPI (LP) group for 3 months.Low-protein diet (LPD) was individualized with total energy intake 125.52-146.44 kJ·kg-1 ·d-1,and protein intake of 0.6-0.8 g·kg-1·d-1.α-keto acid was supplied in a dosage of 0.1 g·kg-1·d-1.Nutritional indexes were recorded and other clinical indexes were measured to evaluate the efficacy and safety respectively. Results The urine protein excretion level and microalbuminuria were significantly decreased at the end of the observation period in the sLP group compared to the basal value and the LP group [24 h urine protein:baseline (4.52±1.74) g,the 1st month (3.19±1.52) g,the 2nd month (2.19±1.1) g,the 3rd month (1.64±0.77) g,P＜0.05; microalbuminyria:baseline (2855.43±248.03) mg/L,the 1st month (2157.14±218.15) mg/L,the 2nd month (1681.57±146.18) mg/L,the 3rd month (924.29±83.33) mg/L,P＜0.05].No significant difference was found in Scr and eGFR.Nutritional indexes (SGA,serume albumin) were significantly higher at the end of 3 months in the sLP group (P＜0.05).No obvious side-effect occurred. Conclusions Short-term restriction of DPI is safe,and when combined with α-keto acids,can increase serum protein and decrease urine protein excretion in chronic hepatitis B patients complicated with CKD without significant sideeffect.
