Clinical study of Coix Seed Extract combined with transcatheter arterial chemoembolization in the treatment for hepatomatic metastasis
10.3760/cma.j.issn.1006-9801.2012.04.007
- VernacularTitle:薏苡仁提取物联合经导管肝动脉化疗栓塞术治疗转移性肝癌的临床研究
- Author:
Haiying JIANG
;
Yanni ZHANG
;
Juan XU
;
Feng HAN
;
Aijun GUO
;
Xiaodong XIE
;
Yanfang LI
;
Wenguang LI
;
Feng LI
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Semen coicis;
Plant extracts;
Embolization,therapeutic;
Vascular endothelial growth factor
- From:
Cancer Research and Clinic
2012;24(4):239-242
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical therapeutic efficacy and adverse reactions of Coix Seed Extract combined with transcatheter arterial chemoembolization(TACE) in the treatment for hepatic metastases and to compare the levels of serum VEGF of the patients before and after the treatment.Methods FromJuly 2009 to July 2011, 62 patients with hepatomatic metastases were enrolled in this study and were randomized into combining group and control group.The combining group were treated by TACE combined with Coix Seed Extract, and the control group were treated with TACE only. Both groups underwent TACE at least twice.Before and after the treatment,the enzyme linked immunosorbentassay(ELISA)was used to examine the change of VEGF. Results Among 62 assessable patients, overall response rate was 61.3 ％(19/31) in combining group and 45.2 ％ (14/31)in control group respectively (P＞ 0.05).The disease control rate was 80.6 ％(25/31) in combining group and 54.8 ％ (17/31) in control group(P＜0.05).The 1-year survival rates were 67.7 ％(21/31) in combining group and 38.7 ％(12/31) in control group(P ＜ 0.05).The median PFS(progression free survival time) was 7.0 months in combining group and 5.1 months in control group (P＜ 0.05).The levels of serum VEGF in combining group were significantly decreased after treatment (P ＜ 0.05). There was no significant difference between the levels of serum VEGF before and after treatment in control group(P＞ 0.05).The levels of serum VEGF in combining group after treatment were lower than that in control group after treatment (P ＜ 0.05). Adverse reactions in both groups were grade Ⅰ to Ⅲ.The fatigue,anorexia and the right upper quadrant pain was significantly superior in combining group. Conclusion Coix Seed Extract combined with transcatheter arterial chemoembolization in the treatment of hepatomatic metastases can improve disease control rate,decrease the levels of serum VEGF,improve clinical symptoms,prolong the PFS and 1-year survival rate.
