Effects of different concentrations of lauromacrogol intravenous injection on thrombosis and vascular wall
10.3760/cma.j.issn.1671-0290.2012.03.010
- VernacularTitle:不同浓度聚桂醇注射后对血管及血栓形成的影响
- Author:
Ke CHEN
;
Shihai CHEN
;
Haisheng YU
;
Hebin QI
- Publication Type:Journal Article
- Keywords:
Lauromacrogol;
Sclerotherapy;
Vein;
Vascular endothelial growth factor (VEGF)
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2012;18(3):190-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different concentrations of lauromacrogol intravenous injection on the thrombosis and vascular walls through the animal experiment.Methods Thirty ear marginal veins of rabbits whose weight ranged from 2.5 kg to 3.0 kg and whose sex was not limited were divided randomly into six groups:1.0 ％ lauromacrogol group,0.9 ％ lauromacrogol group,0.8 ％ lauromacrogol group,0.7 ％ lauromacrogol group,0.6 ％ lauromacrogol group and normal saline group.The local veins and their side tissue were cut off for samples for HE staining and VEGF expression detected by immunohistochemistry at the first day,third day,fifth day and seventh day after injection.Results Visual observation and HE staining showed that 1.0 ％ lauromacrogol group,0.9 ％ lauromacrogol group,0.8 ％ lauromacrogol group and 0.7 ％ lauromacrogol group had thrombosis in veins after injection,0.6 ％ lauromacrogol group and normal saline group did not have thrombosis in veins after injection.The score of VEGF expression showed that 1.0 ％ lauromacrogol group,0.9 ％ lauromacrogol group,0.8 ％ lauromacrogol group and 0.7 ％ lauromacrogol group did not have statistically significant differences between groups and different time point (P＞ 0.05) and there were statistically significant differences between 0.6 ％ lauromacrogol group and other four groups (P＜0.05) in each time point.Conclusions From these animal experiments lauromacrogol shows the effect of vascular injury and thrombosis,eventually leading to the injected vein disappeared in 0.7 ％ lauromacrogol group.
