Nitroglycerin for prevention of post-ERCP pancreatitis and hyperamylasemia

VernacularTitle:硝酸甘油预防经内镜逆行胰胆管造影术后胰腺炎及高淀粉酶血症的临床对照研究
Author: Xiaowei CHEN ; Wandong HONG ; Xiaoli WU ; Qingke HUANG ; Qihuai ZHU ; Zhiming HUANG
Publication Type:Journal Article
Keywords: Nitroglycerin; Cholangiopancreatography,endoscopic retrograde; Pancreatitis; Hyperamylasemia
From: Chinese Journal of Digestive Endoscopy 2012;29(4):181-184
CountryChina
Language:Chinese
Abstract: Objective To study the preventive effects of Nitroglycerin (NTG) on post-ERCP pancreatitis (PEP) and hyperamylasemia.Methods A total of 150 patients were enrolled and randomly divided into 2 groups to receive buccal NTG 0.5mg (NTG group) or buccal Vitamin C 0.1 g (control group).Incidence of PEP and hyperamylasemia and adverse reactions were observed.Results Three patients were excluded according to the exclusion criteria. The overall incidcnces of PEP and hyperamylascmia were 16.3％ (24/147) and 28.6％ (42/147),respectively.The incidence of hyperamylasemia in NTG group (15/74,20.3％) was significantly lower than that of control group (27/73,37.0％) (x2=5.032,P=0.025).Incidence of PEP in NTG group (12.2％) was lower than that of control group (20.5％) without significance (x2=1.892,P=0.169).No severe adverse effects was observed.Conclusion NTG can effectively prevent post-ERCP hyperamylaemia,but its effect on PEP is limited.