The event-related potential P300 and cognition in patients with vascular cognitive impairment-no dementia before and after cognitive rehabifitation training
10.3760/cma.j.issn.0254-1424.2012.04.014
- VernacularTitle:血管性非痴呆型认知障碍患者认知康复后P300与认知功能的研究
- Author:
Yunxia LIU
;
Qixiu ZHU
;
Peiyuan LI
;
Qiang WANG
- Publication Type:Journal Article
- Keywords:
Event-related potential,P300;
Cognitive impairment,vascular;
Assessment;
Rehabilitation training
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2012;34(4):286-290
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of cognition and auditory event-related potential P300 on vascular cognitive impairment-no dementia (VCIND) patients before and after cognitive rehabilitation training,then further to explore the application value of P300 in early diagnosis of vascular cognitive impairment (VCI). MethodsA total of 57 patients with VCIND were randomly assigned to the treatment group ( n =30) and the control group ( n =27),and 30 healthy volunteers without cognitive deficits were recruited as normal group.Each patient was examined with auditory-P300 and scored with mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) scale.The measurement indicators were analyzed and evaluated with the factors of education,age and so on. ResultsThe P300 latency in VCIND group was longer,and the amplitude lower than those in normal group before treatment (P＜0.05 ),the latency lengthening was more significant than the lowering of the amplitude ( P＜0.01 ).The cognitive assessment scale scores of MMSE,MoCA and ADL (Barther index,BI) in VCIND group were lower than those in normal group (P＜0.05),while no significant difference was revealed between the VCIND and normal groups with regard to naming and speech( P ＞ 0.05 ).A highly positive correlation between age and P300 latency as well as a significantly negative correlation between years of education and P300 latency were demonstrated( P＜0.05 ).After cognitive rehabilitation therapy the P300 latency in VCIND group was shortened,the amplitude increased (P＜0.05 ),scores of the items of cognitive scale raised(P＜0.05 ) and the change of each indicator was more statistically significant in treatment group(P＜0.05). ConclusionP300 could objectively reflect early cognitive dysfunction in VCIND patients.Early cognitive training could effectively promote cognitive function of VCI patients.
