Analysis of prognostic influencing factors for early non-small-cell lung cancer after radiotherapy
10.3760/cma.j.issn.1006-9801.2012.03.011
- VernacularTitle:早期非小细胞肺癌放疗预后影响因素分析
- Author:
Hongyun ZHANG
;
Shengmin LAN
;
Jianzhong CAO
;
Hongwei WANG
;
Shuhui REN
;
Ping LU
;
Xiudong GUO
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Radiotherapy,conformal;
Prognosis;
Factor analysis,statistical
- From:
Cancer Research and Clinic
2012;24(3):182-185
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognosis influencing factors of early non-small cell luny cancer (NSCLC) after radiotherapy.Methods 81 early NSCLC patients received definitive radiotherapy and were eligible.Among these patients,60 were diagnosed as squamous cell carcinoma,16 were adenocarcinoma and 5 were diagnosed through imaging instead of pathology.45 patients received conventional radiotherapy,36 patients received three dimensional conformal radiotherapy (3D-CRT),All of them received a total dose of 50-96 Gy with a median dose of 67.8 Gy. Kaplan-Meier survival curves and Cox regression model analysis were applied to evaluate the survival and prognostic factors. Results The median survival time was 34 months.The 1-,3- and 5-year survival rates (OS) were 88.7 ％,41.9 ％,21.8 ％,respectively.Karnofsky performance status≥80,Clinical stage, diameter≤4 cm and the therapeutic effect were associated with improving overall survival.Cox hazards model showed that Karnofsky performance status≥ 80 and diameter≤4 cm were likely to be independent positive prognostic factors. Conclusion Karnofsky performance status and tumor diamater can be used to evaluate the prognosis of early NSCLC after radiotherapy.
