Expression of p21-activated kinase 1 protein in pancreatic cancer and its significance

VernacularTitle:p21活化激酶1在胰腺癌中的表达及其意义
Author: Jun XIAO ; Gantao CHEN
Publication Type:Journal Article
Keywords: Pancreatic neoplasms; p21-activated kinase
From: Cancer Research and Clinic 2012;24(4):250-251
CountryChina
Language:Chinese
Abstract: Objective To investigate the role of PAK1 in the development of pancreatic cancer.Methods 33 cases of pancreatic cancer in Renmin Hospital of XianTao were selected in this study. 33cases of pericancerous normal tissues were collected as control group.Immunohistochemical staining were performed to detect the expression of PAK1 in 33 cases of pancreatic cancer and pericancerous normal specimens.Results By Immunohistochemical staining PAK1 were mainly expressed in the cytoplasm. The positive rate of PAK1 expression in pancreatic cancer were 69.7 ％(23 / 33),which was significantly higher than that of control group[27.3 ％(9 / 33),x2=11.89,P =0.001].In addition,overexpression of PAK1 was more frequently in Ⅲ+Ⅳ stage pancreatic cancer tissue[93.3 ％(14/15)],compared with Ⅰ + Ⅱ stage [50.0 ％( 9 / 18 ),x2=5.367,P=0.021]. Conclusion The PAK1 protein may be associated with the occurrence and development of pancreatic cancer.