Clinical analysis of 43 episodes of cyst infection in autosomal dominant polycystic kidney disease
10.3760/cma.j.issn.1001-7097.2012.03.003
- VernacularTitle:常染色体显性遗传多囊肾病肾囊肿感染43例次临床分析
- Author:
Tong ZHANG
;
Shu RONG
;
Yiyi MA
;
Haipeng SUN
;
Liangliang HE
;
Lanjun LI
;
Zhou CHEN
;
Ye CHEN
;
Shengqiang YU
;
Lin LI
;
Chaoyang YE
;
Chenggang XU
;
Xuezhi ZHAO
;
Changlin MEI
- Publication Type:Journal Article
- Keywords:
Polycystic kidney disease;
Infection;
Therapy;
Retrospective study
- From:
Chinese Journal of Nephrology
2012;28(3):174-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the clinical characteristics and outcome of renal cyst infection in patients with autosomal dominant polycystic kidney disease (ADPKD). Methods Clinical data of 40 ADPKD patients with 43 episodes of renal cyst infection admitted in Shanghai Changzheng Hospital from 1st January 1991 to 31st December 2010 were retrospectively analyzed.Differences of microbiological data and treatments between 1st January 1991 to 31st December 2000 and 1st January 2001 to 31st December 2010 were compared. Results Among 473 identified patients with ADPKD and 662 episodes of hospitalization,40 patients had 43 episodes of renal cyst infection,including 8 definite and 35 likely cases.Microbiological documentation was available for 34 episodes (79.0％),Escherichia coli accounting for 82.4％ of all retrieved bacterial strains.Resistant Escherichia coli to quinolone and certain β-lactamine increased in recent decade.Clinical efficacy of initial antibiotic treatment was noted in 69.8％ of episodes. Antibiotic treatment modification was more frequently required for patients receiving initial monotherapy compared with those receiving combination therapy.In the first ten-year group,initial combination therapy and clinical efficacy were noted in 30.0％ and 60.0％ of episodes respectively,and hospital stay was (20.2±6.7) d.In the second ten-year group,initial combination therapy and clinical efficacy were noted in 61.9％ and 78.2％ of episodes respectively,and hospital stay was (16.3±3.2) d.Large infected cysts (diameter ＞5 cm) frequently required drainage. Conclusions In renal cyst infection,the source of the organisms is often a gram negative enteric organism.Empiric therapy is often initiated with two antibiotics.The drainage of large infected cysts remains the main treatment for cyst infection.
