The effects of repeated irradiation with focused trasound on recurrent and metastasized murine cervical carcinoma

VernacularTitle:二次聚焦超声辐射对小鼠宫颈癌U14肿瘤复发和转移的影响
Author: Xi XIONG ; Bin PENG ; Chuan LIN ; Yu GUO ; Bei ZHAI ; Jiamo ZHANG ; Chengzhi LI
Publication Type:Journal Article
Keywords: Focused ultrasound; Mice; Uterine neoplasms; Recurrence; Metastasis
From: Chinese Journal of Physical Medicine and Rehabilitation 2012;34(3):190-192
CountryChina
Language:Chinese
Abstract: Objective To investigate the efficacy of twice irradiating with focused ultrasound on recurrent and metastasized U14 cervical cancer implanted in the legs of mice. Methods Seventy-two mice with U14 cervical cancer cells implanted in their legs were divided into three groups randomly,with 24 rats in each group.One group received a single dose of focused ultrasound,while mice in the second group were irradiated twice and surgery resection was administered to the third group 7 or 8 days after the tumor was implanted.After 23 days post implantation of the tumor,local tumor recurrence and metastasis to the lungs and lymph nodes were evaluated. Results The inhibition rate after double irradiation was 61.70％ for local recurrence and 68.18％ for metastasis,significantly higher than in the other two groups. Conclusions Both single and double irradiation with focused ultrasound are effective for inhibiting local recurrence and metastasis,but double irradiation is more effective.