Clinical characteristics of gastric mucosa-associated lymphoid tissue lymphoma and the effects of Helicobacter pylori eradication therapy
10.3760/cma.j.issn.1007-5232.2012.03.012
- VernacularTitle:胃黏膜相关淋巴组织淋巴瘤的临床特点及单纯根除幽门螺杆菌治疗的价值分析
- Author:
Guangxia CHEN
;
Kui JIANG
;
Bangmao WANG
;
Weili FANG
;
Wentian LIU
;
Zhongqing ZHENG
;
Mingfang ZHANG
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Gastric mucosa-associated lymphoid tissue lymphoma;
Three-year survival rate;
Clinical Features
- From:
Chinese Journal of Digestive Endoscopy
2012;29(3):155-158
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo review the clinical characteristics of patients with gastric mucosa-associated lymphoid tissue(MALT) lymphoma and to investigate the effects of Helicobacter pylori (Hp) eradication therapy in these patients.MethodsClinical data of ninety-five patients with gastic MALT lymphoma were reviewed with respect to their clinical manifestations,endoscopic features,histopathological features and Hp infection.The follow-up data of patients treated by Hp eradication therapy were analyzed.The survival curve was calculated with Kaplan-Meier,while the predictive factors for resistance to Hp eradiation were then analyzed by using Cox proportional hazards model.ResultsThe clinical manifestations and endoscopic features of 85 patients with gastric MALT lymphoma were non-specific.Hp positive was found in 97.9％ (93/95) patients at presentation,and 36 patients were treated by Hp eradication with a median follow-up duration of ( 58.1 ± 29.9) months.Total remission was achieved in 94.4％ ( 34/36),including 24 complete remission 10 partial remission.Therapy failure occurred in 2 patients.3-year survival rate of patients treated by Hp eradication were 86.2％ (25/29). Cox multivariate analysis showed that age ( ≥60 years),multiple lesions and non-superficial lesions were independent predictors of resistance to Hp eradication therapy.ConclusionGastric MALT lymphoma is associated with Hp infection.Eradication of Hp can effectively induce remission in these patients.
