Correlation analyses among Capsule Endoscopy Scroring Index, simplified Crohn Disease Activity Index and C-reactive protein in small bowel Crohn disease
10.3760/cma.j.issn.1007-5232.2012.03.002
- VernacularTitle:胶囊内镜评分指数与简化克罗恩病活动指数、血清C反应蛋白评估小肠克罗恩病病变活动程度的相关性分析
- Author:
Li YANG
;
Zhizheng GE
;
Yunjie GAO
;
Xiaobo LI
;
Jun DAI
;
Yao ZHANG
;
Hanbing XUE
;
Yunjia ZHAO
- Publication Type:Journal Article
- Keywords:
C-reactive protein;
Capsule endoscopy scoring index;
The simplified Crohn disease activity index;
Small bowel Crohn disease
- From:
Chinese Journal of Digestive Endoscopy
2012;29(3):126-129
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the correlation between any two of Capsule Endoscopy ScroringIndex (Lewis score),simplified Crohn Disease Activity Index (CDAI) and C-reactive protein (CRP) in small bowel Crohn disease (CD).MethodsA total of 58 consecutive patients with known small bowel CD were enrolled. We evaluated disease activity with Lewis score and simplified CDAI. Correlations among CRP,simplified CDAI and Lewis score were calculated with Spearman's rank order correlation coefficient.The optimal CRP cut-off value was calculated using the ROC curve.ResultsThe Lewis score showed inactive,mild and moderate-severe patients were 13,21 and 24,respectively.CRP of moderate-severe group was significantly higher than that in mild and inactive groups ( P ＜ 0.05 ).The optimal CRP cut-off value that differentiated patients with moderate to severe disease from the others was 13.50 mg/L with sensitivity of 87.5％ and specificity of 82.4％.The area under the ROC curve to analyze the cut-off was 0.849.Lewis score was moderately correlated with CRP (r =0.58,P ＜ 0.01 ),and weakly correlated with the simplified CDAI (r =0.40,P ＜ 0.01 ).ConclusionSerum CRP and the simplified CDAI cannot replace Lewis score for capsule endoscopy in the assessment of disease activity in small bowel CD.However,CRP may be considered as an inflammatory marker for evaluating the moderate to severe capsule endoscopic activity.
