Correlative factors for early progressive motor deficits in cerebral infarction in basal ganglia
10.3760/cma.i.issn.1006-7876.2012.03.004
- VernacularTitle:基底节区脑梗死患者早期运动障碍加重的相关因素分析
- Author:
Yan WANG
;
Xinjiang ZHANG
;
Wei WANG
;
Cheng LI
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Movement disorders;
Magnetic resonance imaging;
Risk factors
- From:
Chinese Journal of Neurology
2012;45(3):158-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective Comparative analysis for the risk factors associated with early progressive motor deficits in cerebral infarcts of different sizes in white matter of basal ganglia region and the relation between infarctions and middle cerebral artery stem lesions.Methods All 120 patients with single acute infarction located in white matter of basal ganglia region were recruited in this study retrospectively.All patients had brain and neck magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) within 72 h after onset.They were divided into two groups:the first group ( n =60,maximal size of infarctions in diameters were from 1.5 cm to 3.0 cm) and the second group (n =60,maximal diameters ＜1.5 cm) based on the maximal diameters of the infarctions on diffusion weighted imaging (DWI).Dynamic National Institutes of Health Stroke Scale (NIHSS) in 7 days after the admission were evaluated,and analyzed by multiple Logistic regression to estimate the independent contribution of the risk factors to the early progressive motor deficits.Then,each of 2 groups was subdivided into 5 subgroups according to the MRA and clinical symptoms.Correlation between infarction and extracranial-intracranial artery lesion was analyzed.Results The proportion of patients with early progressive motor in the first group was significantly higher than that in the second group (19/60,31.6％ vs 5/60,8.3％,x2 =4.671,P=0.001 ).By multiple logistic regression analysis,elevated systolic blood pressure on admission( odds ratio(OR) =5.42,95％confidence interval (CI) 1.507-10.063,P =0.016) was independently related to early progressive motor deficits.The proportion of middle cerebral atery stem lesion in the first group was significantly higher than that in the second group(24/60,40.0％ vs5/60,8.3％,x2=0.916,P=0.000).Concltusions Patientswith acute single infarction located in white matter of basal ganglia and with diameters of 1.5 cm to 3.0 cm are at higher risk of early progressive motor deficits.Elevated systolic blood pressure on admission is the most significant independent factor related to early progressive motor deficits.The pathogenic mechanism of these middle size infarctions may be associated with lesions in middle cerebral artery stem.
