Expression of EZH2 gene in cervical squamous carcinoma and its clinicopathologic significance
10.3760/cma.j.issn.1006-9801.2012.02.005
- VernacularTitle:EZH2基因在子宫颈鳞状细胞癌中的表达及其意义
- Author:
Lanyu LI
;
Wei ZHANG
;
Wanru GUO
;
Wenting ZHANG
;
Yajuan ZHONG
- Publication Type:Journal Article
- Keywords:
Gene,EZH2;
Cervix uteri;
Carcinoma,squamous cell;
Eeverse transcriptase polymerase chain reaction
- From:
Cancer Research and Clinic
2012;24(2):88-90
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the expression of EZH2 gene in cervical squamous carcinoma and its clinicopathologic significance. MethodsThe expression of EZH2 mRNA was detected in 21 samples of normal cervical tissue, 27 samples of CIN tissue and 48 samples of cervical squamous carcinoma tissue by RT-PCR. And the relationship between EZH2 expression and the clinical pathological characteristic was analyzed. ResultsThe level of EZH2 mRNA in cervical squamous carcinoma tissues(1.67±0.01)were significantly higher than that in the normal cervical tissues (0) and CIN tissues (0.36±0.02) (P ＜ 0.01).There was no correlation between EZH2 and ages (P ＞ 0.05), while the expression of EZH2 was highly correlated with histologic stage,clinical stage,muscular invasion depth and lymph node metastasis of cervical squamous carcinoma (P ＜ 0.01).ConclusionThe over-expression of the EZH2mRNA may play an important role in the pathogenesis and progression of cervical squamous carcinoma,suggesting that EZH2 might be a new biomarker for diagnosing cervical squamous carcinoma.
