Application of aptamers in the study of autoimmune diseases
10.3760/cma.j.issn.1009-9158.2012.03.005
- VernacularTitle:适配子技术在自身免疫性疾病研究中的应用
- Author:
Kaiyu WANG
;
Xiaopeng LAN
- Publication Type:Journal Article
- Keywords:
Autoimmune diseases;
Aptamers,nucleotide;
Autoantibodies;
SELEX aptamer technique
- From:
Chinese Journal of Laboratory Medicine
2012;35(3):212-215
- CountryChina
- Language:Chinese
-
Abstract:
Aptamers are oligonucleotides or peptides those are able to bind tightly,by their specific three-dimensional shapes,to a variety of targets.Because of numerous merits ( high affinity,high specificity,small size,little immunogenicity,stable structures,and ease of synthesis),aptamers represent a valid alternative to antibodies and become a valuable research tool and show great application to fundamental research,drug selection and clinical diagnosis and therapy.The review describe the applications and the possible applications of aptamers in the diagnosis,treatment and pathogenesis of autoimmune diseases.
