Molecular characteristics of HBV variants under the selective pressure and its significance
10.3760/cma.j.issn.1009-9158.2012.02.005
- VernacularTitle:选择压力下乙型肝炎病毒变异的分子特征及其意义
- Author:
Yu CHEN
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Variation(genetics)
- From:
Chinese Journal of Laboratory Medicine
2012;35(2):122-125
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus has a high degree of genetic variation. Multiple selection pressure,exerted by vaccine,antiviral drugs and diagnostic reagents,might favor certain mutations of HBV. HBV variation under the selective pressure may affect the pathogenesis of HBV-related liver disease,immunization effect,antiviral efficacy and laboratory tests.In this paper,we summarize the molecular characteristics and its significance of HBV variants,which will help us to manage hepatitis B.
