Study on the application and compliance of statins in secondary prevention of ischemic stroke and transient ischemic attacks
10.3760/cma.j.issn.1006-7876.2012.02.008
- VernacularTitle:他汀类药物在缺血性卒中和短暂性脑缺血发作二级预防中的应用现状及其依从性
- Author:
Bo SONG
;
Guang YANG
;
Yuan GAO
;
Jiameng LU
;
Song TAN
;
Shuo LI
;
Siyuan CHANG
;
Yuming XU
- Publication Type:Journal Article
- Keywords:
Stroke;
Ischemic attack,transient;
Hydroxymethylglutaryl-CoA reductase inhibitors;
Patient compliance
- From:
Chinese Journal of Neurology
2012;45(2):107-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application of statins in secondary prevention of ischemic stroke and transient ischemic attacks (TIA) in different risk groups,and to identify the factors influencing the compliance of statins. Methods Data were prospectively collected on consecutively encountered ischemic stroke or TIA patients admitted to the First Affiliated Hospital of Zhengzhou University from April 2009 to January 2010.All clinical characteristics and possible factors influencing the compliance of statins were collected; the application of statins was investigated at 3-month follow-up.The multivariate Logistic regression analysis was used for the analysis of influence factors of the compliance of statins.Results All 369 patients were collected,52.8％ of cases were prescribed statins for therapy during hospitalization.The application rate of statins in accordance with guidelines in high-risk group,extremely high-risk Ⅱ group and extremely high-risk Ⅰ group was 25.0％ (16/64),44.1％ (30/68) and 71.4％ (135/189),respectively. Logistic regression analysis showed that the statins application during hospitalization was associated with diabetes history ( P =0.032,OR =1.789,95％ CI 1.052-3.043 ) and the presence of carotid vulnerable plaques(P =0.000,OR =5.308,95％ CI 3.340-8.434).The general application rate of statins was 22.3％ (81/363),which was significantly lower than that during hospitalization. The application rate of statins in accordance with guidelines in high-risk group,extremely high-risk Ⅱ group and extremely high-risk Ⅰ group was 9.7％ ( 6/62 ),25.8％ (17/66) and 29.4％ (55/187) respectively.Logistic regression analysis showed that good compliance of statins was associated with discharge instructions on statins application ( P =0.000,OR =34.852,95％ CI 14.673-175.452 ). Conclusions The compliance of statins in secondary prevention of ischemic stroke and TIA is poor,and there is still a large gap between clinical practice and guidelines; Discharge instructions on statins application increase the compliance of statins.
