Clinical and muscular pathological features with chronic graft-versus-host disease-related polymyositis: one case report
10.3760/cma.j.issn.1006-7876.2012.02.011
- VernacularTitle:慢性移植物抗宿主病相关性多发性肌炎一例临床和骨骼肌病理特点
- Author:
Lingchao MENG
;
Wei ZHANG
;
Zhaoxia WANG
;
Feng GAO
;
Yun YUAN
- Publication Type:Journal Article
- Keywords:
Graft vs host disease;
Polymyositis;
Muscle,skeletal;
Haematopoietic stem cell transplantation
- From:
Chinese Journal of Neurology
2012;45(2):116-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report the clinical and pathological features of chronic graft-versus-host disease-related polymyositis by summarizing the clinical data of the patient with chronic graft-versus-host disease-related polymyositis. Methods One patient with chronic graft-versus-host disease-related polymyositis was hospitalized in our hospital on December 29,2010.The patient,40 years old,female,underwent allogeneic haematopoietic stem cell transplantation because of acute granulocytic-monocytic leukemia.Fourteen months later she manifested as slowly progressive muscle weakness and myalgia in all limbs.Serum creatine kinase level was between 426-1948 U/L. Myositis antibody EJ was strongly positive.Electromyogram showed a neurogenic impairment and slow peripheral nerve conduction speed.Muscle biopsies were carried out in the left biceps brechii.In addition of standard histological and enzyme histochemical staining for the muscle sections,immunohistochemical workup was performed with mouse antiCDs,anti-CD20,anti-CD68 and anti major histocompatibility complex- Ⅰ ( MHC- Ⅰ ) monoclonal antibodies as first antibodies.Results The muscle biopsy showed large variation of fiber size,with muscle fiber necrosis,regeneration.Some angular fibers distributed in small cluster.The inflammatory cells infiltrated around the small vessel or in the endomysium,mainly CD8+ T-lymphocytes and CD6+8 macrophages.The most muscle fibers were MHC-Ⅰ positive. Conclusion The graft-versus-host disease-related polymyositis manifests as chronic myositis process with neurogenic lesions.
