Literatures analysis of clinical significance of lymph node metastasis in gastrointestinal stromal tumor

VernacularTitle:胃肠道间质瘤淋巴结转移临床意义文献分析
Author: Yanjun LU ; Xiaobo LIANG ; Liang YUE ; Xiaoyuan WANG ; Zhenhua WANG
Publication Type:Journal Article
Keywords: Gastrointestinal stromal tumors; Lymphatic metastasis; Clinical significance
From: Cancer Research and Clinic 2012;24(1):8-11
CountryChina
Language:Chinese
Abstract: ObjectiveTo explore the clinical significance of lymph node metastasis in gastrointestinal stromal tumor (GIST).Methods A literature search to identify studies relating to GIST cases reported between January 1998 and December 2010 was conducted.The associations between lymph node metastasis and GIST clinicopathological features, gene expression, GIST stage, and GIST prognosis were evaluated.Results 6063 literatures were screened and only 16 GIST patients (median age of 49.25 years,10females) with lymph node metastasis were enrolled in this study.Among them,12 tumors were located in the stomach, 3 in the small intestine, and 1 in the esophagus.Morphologically, 13 specimens were mainly characterized by spindle cells.Gene analysis was examined in 7 cases.Conclusions Lymph node metastasis in GIST might more frequently found in the stomach, tumor stage of high grade, and cellular morphology of spindle-shaped.Gene mutation may have a relationship with lymph node metastasis.However, its clinical significance remains unclear.