Influence of liposome PGE1 on ischemia-reperfusion injury of expanded flap

VernacularTitle:脂质体携载前列腺素E1对扩张皮瓣缺血-再灌注损伤的影响
Author: Weiwei LI ; Zhifei LIU ; Qun QIAO ; Xiaojun WANG ; Lin ZHU ; Ang ZENG ; Hailin ZHANG ; Ming BAI ; Rui FENG
Publication Type:Journal Article
Keywords: Prostaglandin El; Expanded flap; Ischemia-reperfusion injury
From: Chinese Journal of Medical Aesthetics and Cosmetology 2012;18(1):44-47
CountryChina
Language:Chinese
Abstract: Objective To investigate the influence of the liposome PGE1 on the ischemia-reperfusion injury of the expanded flap.Methods The minipigs were set up as an animal model.They were divided into 2 groups.The expanded flaps (8 cm × 2 cm ) was designed and elevated on the back of the minipigs.An image analysis technology was used to evaluate the survival rate of the expanded flap,while a biochemistry method was used to detect the concentrations of malondialdehyde (MDA),myeloperoxidase (MPO) and microvessel density (MVD) in the tissue.Skin tempreture was measured after the drug administration.Results The survival area of the expanded flap in the Lipo PGE1 group was significantly enlarged (P＜0.05),compared with the control group.The MPO and MDA concen tration in the tissue was statistically different between two groups (P＜ 0.05),but there was no difference of the MVD concentration between two groups.The skin temperature was higher in the Lipo PGE1 group.Conclusions The Lipo PGE1 could promote survival rate in the expanded flap and protect it from ischemic injury.