Histological study of sciatic nerve regeneration repaired in different size by artery sleeve briding
10.3760/cma.j.issn.1001-2036.2011.06.014
- VernacularTitle:坐骨神经不等径小间隙动脉套接吻合后再生时相的组织学观察
- Author:
Yan LIU
;
Zhiyong LUAN
;
Decong ZHANG
;
Weitian YIN
;
Biao LIU
- Publication Type:Journal Article
- Keywords:
Sciatic nerve;
Artery sleeve bridging;
Nerve regeneration
- From:
Chinese Journal of Microsurgery
2011;34(6):476-478
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveBy the study of histological feature of the regenerated nerve at different time after operation,to explore the mechanism of the peripheral nerve regenerationwhen the distal nerve stump is repaired by a smaller proximal end with artery sleeve briding.MethodsFour Wistar rats were served as the donors of arteris for bridging.Sixteen Wistar rats were randomized into 2 groups (n =8 per group).In control group,the right sciatic nerves were cut off and received epineurial suture.In experimental group,the right sciatic nerves received artery sleeve bridging in different size.HE staining was taken to observe the histological changes of the regenerated nerve at 7,14,21 and 28 days after operation.ResultsThe new regenerated axons need about 21 days to pass the bridging gap.Twenty-eight days after operation,the number of the regenerated axons in distal segment was greater than that of the proximal in the experimental group.The regenerated axons were matured and more regular.Conclusion The functional reserve of repaired nerve is exists when the proximal end is smaller than the distal in size by means of amplification effect.And the method of artery sleeve bridging provides a better situation for functional reserve.
