Association study of RANKL rs7984870 polymorphism and risk of rheumatoid arthritis
10.3760/cma.j.issn.0254-5101.2011.12.004
- VernacularTitle:核因子-κB受体激活因子配体基因多态性与类风湿关节炎易感性的研究
- Author:
Hui ZHANG
;
Nanwei XU
;
Ruiping LIU
- Publication Type:Journal Article
- Keywords:
RANKL;
Rheumatoid arthritis;
Matrix-assisted laser desorption/ionization time-offlight mass spectrometry;
Single nucleotide polymorphism
- From:
Chinese Journal of Microbiology and Immunology
2011;31(12):1072-1075
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo elucidate the association between RANKL rs7984870 C ＞G polymorphism and the susceptibility to rheumatoid arthritis in a Chinese Han population.MethodsGenotypes were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) method in 214 rheumatoid arthritis cases and 478 controls.ResultsThe RANKL rs7984870 C＞G genotype frequencies were 27.3% ( CC),51.2% ( CG),21.5% (GG) in the rheumatoid arthritis group and 25.3% (CC),49.1% (CG),25.7% (GG) in the control group respectively; Logistic regression analyses revealed that the risk associated with RANKL rs7984870 C＞G variant genotype was 0.78 (95% CI =0.49-1.24) for RANKL rs7984870 GG compared with its wild-type homozygote.ConclusionRANKL rs7984870 polymorphism may not serve as a risk factor of rheumatoid arthritis susceptibility.Further functional studies are warranted to verify our findings.
