Expression and clinical significance of diacylglycerol kinase a and protein kinase C in hepatocarcinoma
10.3760/cma.j.issn.1006-9801.2011.12.009
- VernacularTitle:二酰甘油激酶α、蛋白激酶C在肝癌组织中的表达及其临床意义
- Author:
Jinfeng MA
;
Kai JIA
;
Yanfeng XI
;
Huilin CUI
- Publication Type:Journal Article
- Keywords:
Diacylglycerol kinase;
Protein kinase C;
Liver neoplasms
- From:
Cancer Research and Clinic
2011;23(12):819-821
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the expression and the clinical significance of diacylglycerol kinase α (DGKα) and protein kinase C (PKC) in human hepatocellular carcinoma (HCC).MethodsDGKα and PKC expressions in the samples from 60 pathologically confirmed HCC patients were analyzed by immunohistochemistry. The relationship between DGKo expression and clinical pathology factors was analyzed.ResultsThe expression positive rates of DGKo and PKC were highest in normal liver tissues [90.0％ (9/10) and 100.0％ (10/10)].The positive rates were 81.7 ％ (49/60) and 71.7 ％ (43/60) in HCC tissues,respectively,and were 58.3 ％ (35/60) and 61.7 ％ (37/60) in carcinoma adjacent tissues,respectively.In three liver tissues,the positive rates of DGKα and PKC were significantly different (P ＜0.05).The location of both kinases in hepatocytes translocated from cytoplasm/nucleus to membrane.The expressions of DGKα and PKC were positively correlation(r =0.495, P ＜ 0.05), The DGKα expression was correlated to differentiation type,portal venous tumor thrombus and TNM staging(all P ＜ 0.05).ConclusionDGKa is expressed with high activity in advanced stage and poorly differentiated HCC. It may be promote the pathological process of HCC.
