Detection of five periodontal pathogens in coronary atherosclerotic plaque
10.3760/cma.j.issn.0254-5101.2011.11.003
- VernacularTitle:牙周致病菌在动脉粥样硬化斑块中的检测
- Author:
Xiuli HOU
;
Ping LIANG
;
Yuanming ZHANG
;
Lati MU
;
Sikaer AI
;
Kebaier AI
;
Yuebin RUN
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Periodontitis;
Periodontal pathogens
- From:
Chinese Journal of Microbiology and Immunology
2011;31(11):967-970
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo detect five periodontal pathogenic bacteria in coronary atherosclerotic plaques.MethodsAtherosclerotic plaque specimens were obtained from 101 patients who scheduled for coronary artery bypass graft surgery.The bacteria DNA was obtained from coronary atherosclerotic plaques using the chelex-100 method.The extracted DNA were examined by PCR.ResultsWithin the 101 pieces of atherosclerotic plaque samples Porphyromonas gingivalis( Pg,31％ ),Tannerella forsythensis(Tf,42％ ),Prevotella intermedia( Pi,26％ ),Fusobacterium nucleatum( Fn,21％ ),Actinobacillus actinomycetemcomitans( Aa,23％ ).PCR products were sequenced and were compared with GenBank sequences,the homology was 99％-100％.ConclusionPeriodontitis might affect the development of atherosclerosis and there is a correlation between coronary heart disease and chronic periodontitis.
