Chemokine receptor CX3CR1-M280 and human cardiovascular diseases
- Author:
Vu Trieu An
- Publication Type:Journal Article
- Keywords:
cardiovascular diseases
- MeSH:
Cardiovascular Diseases;
Chemokines;
Mutation
- From:Journal of Medical and Pharmaceutical Information
2003;0(4):15-16
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
During study in HIV/AIDS, US researchers of National Institute of Allergy and Infectious Diseases found that sometime gene mutations in immune-competent cells could help body have better resistance to cardiovascular diseases. These mutations are in some receptors of chemokines in membrane of immune cells. Results of experimental trial in mouse had gene mutation in receptor CX3CR1 showed that this mutant could make better resistance to high-risk factors and genetic factors in pathogenesis of cardiovascular diseases. This finding provided a new way to study drugs that have effects right on chemokine receptor CX3CR1 of high-risk patients with atherosclerosis
