Manifestations of autonomic nervous system in Lambert-Eaton myasthenic syndrome
10.3760/cma.j.issn.1006-7876.2011.12.009
- VernacularTitle:Lambert-Eaton肌无力综合征的自主神经系统表现
- Author:
Yuzhou GUAN
;
Benhong LI
;
Hua DU
;
Shuang WU
;
Liying CUI
- Publication Type:Journal Article
- Keywords:
Lambert-Eaton myasthenia syndrome;
Autonomic nervous system;
Reflex,abnormal
- From:
Chinese Journal of Neurology
2011;44(12):841-843
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively analyze clinical manifestations of autonomic nervous system (ANS) and skin sympathetic response (SSR) in Lambert-Eaton myasthenic syndrome (LEMS).Methods Fifty-three LEMS patients' medical records were reviewed and information regarding clinical symptoms and signs of ANS and SSR testing results were collected.Results ( 1 ) The most common initial symptom of LEMS was weakness of lower extremities ( n =41 ) and the most common symptom of ANS dysfunction was constipation ( n =25 ) and dry-mouth ( n =23),which could be occurred before the onset of the legs (n =7).(2) In symptoms of ANS,cardiovascular system dysfunction was found in 4 patients include one of ingone of bradycardia,one of postural hypotension and 2 of tachycardia- Secretory glands dysfunction was found in 34 patients:23 dry-mouth,6 dry-eyes,and 8 patients sweating dysfunctions.Twenty-eight patients complained of alimentary dysfunction including constipation and diarrhea.Bladder dysfunction was found in 2 patients,who complained of urinary incontinence.Seven male patients complained of sexual dysfunction.Abnormal skin scratch test was found in 17 patients.(3) SSR was performed in 33 patients and 18 found abnormal.Conclusions ANS manifestations are common and prominent in LEMS patients.SSR abnormality is also common in LEMS.More electrophysiology tests are needed in LEMS patients.
