Short-term clinical efficacy of 125I radioactive seeds implantation in treating the postoperative lung metastases of malignant fibrous histiocytoma

VernacularTitle:125I放射性粒子植入治疗恶性纤维组织细胞瘤术后肺转移瘤的短期效果观察
Author: Jinshuang Lü ; Guangjun ZHENG ; Jingkui YANG ; Zhen FENG ; Shude CHAI
Publication Type:Journal Article
Keywords: Malignant fibrous histiocytoma; lung metastases; 125I radioactive seeds
From: Clinical Medicine of China 2012;28(11):1191-1193
CountryChina
Language:Chinese
Abstract: Objective To investigate the short-term clinical efficacy of CT-guided percutaneous implantation of 125I radioactive seeds in treating the postoperative lung metastases of malignant fibrous histiocytoma(MFH).Methods Eight patients with lung metastases after MFH surgery received CT-guided percutaneous implantation of 125I radioactive seeds.There are 28 metastasis lesions in total.Prescribed dose (PD) was 80 Gy and radioactivity was 0.7 mCi(2.59 × 107 Bq).Six months after implantation,chest CT-scan was performed and the changes were reviewed according to the international standards.ResultsAverage dose received by tumor was ( 172.9 ± 39.9 ) Gy,D100 ( 77.7 ± 10.2 ) Gy and D90 ( 97.2 ± 6.8 ) Gy.The overall response rate was 82.1％.Patients' survival period was 10.0 - 26.0 ( 14.6 ± 3.5 ) months with the median survival time of 13 months.ConclusionIn the treatment of postoperative lung metastases of MFH,implantation of 125I radioactive seeds produces a good short-term clinical efficacy.