Study on intestinal absorption of multiple constituents under the drug response of Wuwei-Jiangya recipe
10.3760/cma.j.issn.1673-4246.2012.09.012
- VernacularTitle:五味降压方在药效反应时肠吸收多成分暴露特征探讨
- Author:
Huihui ZHAO
;
Li YU
;
Kailun ZHANG
;
Changling WEI
;
Yang LIU
;
Baosheng ZHAO
;
Shuofeng ZHANG
;
Xiaoyan GAO
;
Liying LIU
- Publication Type:Journal Article
- Keywords:
Wuwei-Jiangya recipe;
Exposure-response;
Multicomponent;
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- From:
International Journal of Traditional Chinese Medicine
2012;34(9):804-807
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo research the intestinal absorption characteristics in rats of multiple constituents,when Wuwei-Jiangya recipe was used in rats and showed reducing blood pressure effects.Methods ① After extracting Wuwei-Jiangya recipe,we fed it to rats once daily,until the blood pressure reduced; ②Establish Wuwei-Jiangya recipe and intestinal absorption of multiple constituents fingerprint by using reverted gut sac method and RP-HPLC fmgerprint.ResultsAfter one week's administration,there was the hypotensive effects and multiple constituents can be absorbed by intestine.ConclusionWhen the drug works,reverted gut sac method for studying intestinal absorption constituents can be used for locking the exposure constituents.
