The effect of perindopril and metoprolol in the treatment of geriatric chronic heart failure
10.3760/cma.j.issn.1008-6706.2012.18.017
- VernacularTitle:培哚普利联合美托洛尔治疗老年人慢性心力衰竭
- Author:
Silan ZHANG
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Perindopril;
Metoprolol
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(18):2751-2753
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical therapeutic efficacy of perindopril and metoprolol in the treatment of chronic heart failure in old patients( ≥60 years old).Methods 136 old patients( ≥60 years old) with chronic heart failure were randomly divided into the treatment group(n =68) and the control group(n =68).The control group received the routine treatment with digitalis,diuretics and nitroglycerin.The treatment group was given perindopril and metoprolol orally besides the routine treatment.The perindopril was taken orally 2mg per time,and once a day,and gradually raised to maximum does 8mg per time,once a day.The metoprolol was taken orally 25mg per time,twice a day,also gradually raised to maximum dose 25mg per time,twice a day.4-8 weeks were a treatment cycle.The cardiac function,left ventricular ejection fraction ( LVEF),the 6-minute walk and plasma brain natriuretic pep-tide (BNP) were observed before the beginning of the therapy and after,respectively.Results All patients improved their cardiac function,LVEF,plasma BNP and the 6-minute walk significantly after the therapy ( t =2.56,3.23,2.48,2.53,2.79,3.31,all P ＜ 0.05 ).The improvement of the treatment group was more significantly than that of the control group ( t =2.87,3.12,2.59,all P ＜ 0.05 ).The total effective rate of treatment group was 94.1％,significantly higher thar 70.6％ of control group( x2 =5.96,P ＜0.05 ).Conclusion The therapy of perindopril and metoprolol in old patients with chronic heart failure could improve ventvicular remodeling and the effect.
