An experimental study of 10 cGy whole brain radiation induced cognitive dysfunction
10.3760/cma.j.issn.1004-4221.2012.05.023
- VernacularTitle:10 cGy单次全脑照射引起大鼠认知功能损害的初步实验研究
- Author:
Rui SUN
;
Liyuan ZHANG
;
Shengjun JI
;
Liesong CHEN
;
Jianfeng JI
;
Ye TIAN
- Publication Type:Journal Article
- Keywords:
Brain/irradiation;
Cognition function;
Rat
- From:
Chinese Journal of Radiation Oncology
2012;21(5):474-476
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the relationship between 10 cGy whole brain radiation and cognitive dystunction.MethodsThirty-two male Sprague-Dawley rats at age one month were randomized into irradiation and sham exposed groups.Behavioral and histopathological tests were performed 3 months after irradiation in the order of open field,Morris water maze,passive avoidance,and histopathological test.Comparison between the two groups was conducted using independent samples t-test.ResultsIn the place navigation test of Morris water maze,irradiation group showed significantly longer latency than sham exposed group on day 3 and 4 ( t =2.91 and 2.65,all P ＜ 0.05 ).In the total latency of the place navigation,irradiation group also presented longer latency comparing with sham exposed group ( t =2.63,P ＜ 0.05 ).In the spatial probe test of Morris water maze,the open field test and the passive avoidance test showed no significant difference between the two groups ( t =0.92,0.59,0.83,all P ＞ 0.05 ).The histopathological examination had no significant difference either.ConclusionWhole brain radiation of 10 cGy could partly injury the cognitive function of the rat.
