Genetic polymorphisms of interleukin-28B are associated with spontaneous clearance of hepatitis C virus infection
10.3760/cma.j.issn.1000-6680.2012.09.006
- VernacularTitle:白细胞介素-28B基因多态性与丙型肝炎病毒感染自然清除的相关性
- Author:
Junqiang XIE
;
Xiaoyan GUO
;
Xinhua LI
;
Jie LUO
;
Zhiliang GAO
;
Zhixin ZHAO
- Publication Type:Journal Article
- Keywords:
Hepatitis C;
Interleukins;
Polymorphism,single nucleotide;
Genotype;
Alleles
- From:
Chinese Journal of Infectious Diseases
2012;30(9):538-541
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between interleukin (IL)-28B variation and spontaneous clearance of hepatitis C virus (HCV) infection.MethodsA total of 280 HCV infected patients including 200 chronic hepatitis C (CHC) patients and 80 spontaneous clearance patients of HCV infection were enrolled in the study.The rs8099917 single nucleotide polymorphyism (SNP) of IL-28B gene was detected and the association between IL-28B variation and spontaneous clearance of HCV infection was analyzed.The data were compared using chi square test.ResultsThe genotype frequencies of TT and non TT (TG and GG) of IL-28B rs8099917 between CHC patients and spontaneous clearance patients were not significantly different ( x2 =15.874,P ＜ 0.01 ). The prevalence of TT genotype in the spontaneous clearance group was 86.2％,which was higher than that in CHC group (62.0％).T and G allele frequencies in CHC group were 78.0％ and 22.0％,respectively,and those in spontaneous clearance group were 92.5％ and 7.5％,respectively,which indicated that T allele was dominant in spontaneous clearance patients. The allele frequency of rs8099917 was statistically different between the two groups (P＜0.01).The spontaneous HCV clear rate in rs8099917 TT patients was 2.84 folds of non-TT patients,while the risk of chronicity of non-TT (TG+GG) patients was 1.36 folds of TT patients.Conclusion The IL-28B (rs8099917) TT genotype is associated with spontaneous clearance of HCV infection,which can be an important factor to predict the spontaneous clearance of HCV.
