Therapeutic effects of pediatric renal transplantation: A report of 138 cases
10.3760/cma.j.issn.0254-1785.2012.09.009
- VernacularTitle:儿童肾移植138例分析
- Author:
Shu HAN
;
Aimin ZHANG
;
Longgen XU
;
Yifeng GUO
;
Zhihua ZHOU
;
Huaizhou CHEN
;
Jingshu LI
;
Xiangyang JIN
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Child;
Treatment outcome
- From:
Chinese Journal of Organ Transplantation
2012;33(9):544-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summary the clinical data of pediatric renal transplantation from multiple renal transplant centers in China,and analyze the factors influencing the therapeutic outcomes of pediatric renal transplantation.Methods From March 1986 to May 2010,the clinical data of 138 children who underwent renal transplantation in eight centers of renal transplantation in China were retrospectively analyzed.Results The one-year patient and graft survival rate was 99.3％ and 95.7％respectively.Acute rejection episodes occurred in 38 cases (27.5％),15 cases suffered delayed graft function (DGF),and graft functions were returned to normal in all recipients within one month.Moreover,other complications included transplant renal artery stenosis in 8 cases (5.8％),ureteral necrosis in 2 cases (1.4％),urinary fistula in 5 cases (3.6％),hypertension in 57 cases (41.3 ％),hyperlipidemia in 38 cases (27.5％),hirsutism in 32 cases (23.2％),drug-induced liver damage in 26 cases (18.8％),urinary tract infection in 25 cases (18.1％ ),gingival hyperplasia in 22 cases (15.9％),pulmonary infection in 21 cases (15.2％),bone marrow suppression in 12 patients (8.7％),herpes simplex in 10 cases (7.2％),and diabetes in 8 cases (5.8％).The body weight was increased by 4 to 13 kg and the body height was increased by 2 to 7 cm during the first year posttransplantation. Conclusion The careful perioperative management, rational use of immunosuppressive agents,strengthening the follow-up management of children and social support,and improving compliance were the key points to obtain good outcomes in pediatric renal transplantation.
