Comparison of the effect of intervention embolization and operation in the treatment of cerebral aneurysms
10.3760/cma.j.issn.1008-6706.2012.18.003
- VernacularTitle:介入栓塞术与开颅术治疗脑动脉瘤临床疗效比较
- Author:
Qiang GUO
;
Feng JIN
;
Deqin CHEN
;
Shiqing YAN
;
Lingsheng KONG
;
Hao ZHANG
;
Guangkui HAN
- Publication Type:Journal Article
- Keywords:
Intracranial aneurysms;
Embolization,therapeutic;
Nerve surgery
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(18):2725-2727
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare of intervention embolization and operation in the treatment of brain aneurysms.Methods 60 cerebral aneurysm patients using random number table method were divided into two groups each 30 cases,group A given intervention embolization;group B given surgical operation treatment.They were followed for 3months,the bleed Glasgow results score,matrix metalloproteinases 2(MMP-2) level change and the length of time were recorded.Results After treatment,A group total effective rate was 73.4％,postoperative treatment to bleed again rate was 10.0％ (3/30),B group was 76.7％,6.7％ (2/30),two groups had no statistically significant differences (x2 =0.09,0.22,all P ＞ 0.05 ) before treatment M MP-2 level between ;The two groups was statistically significant ( t =1.21,P ＞ 0.05 ) ;Two groups after surgical treatment 3 d MMP-2 levels were ( 20.1 ± 8.7 ) μg/L,( 35.7 ±8.9 ) μg/L respectively,which was statistically significant ( t =3.33,P ＜ 0.05 ).A group of hospitalization time (8.6 ±1.5 ) d,group B ( 13.2 ± 1.3 ) d,the difference between two groups was statistically significant ( t =3.18,P ＜ 0.05 ).Conclusion For brain aneurysm patients,the intervention embolization had no obvious difference in curative effect with operation,but could reduce the time in hospital and significantly reduced MMP-2 level.
