Observation of the effect of tripterygium combined with huangkui capsule in the treatment of diabetic nephropathy

VernacularTitle:雷公藤多苷片联合黄葵胶囊治疗糖尿病肾病疗效观察
Author: Junhui LI
Publication Type:Journal Article
Keywords: Diabetic nephropathy; Tripterygium; Huangkui capsule
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(18):2731-2732
CountryChina
Language:Chinese
Abstract: Objective To observe the effect and safety of tripterygium combined with huangkui capsule in the treatment of diabetic nephropathy.Methods 128 diabetic nephropathy patients were classified into two groups,observation group of 64 cases were treated with tripterygium combined with huangkui capsule and control group of 64 cases were treated with huangkui capsule.The clinical effect,urinary protein between the two groups were compared.Results The total effective rate in observation group ( 82.8％ ) was significantly higher than that in control group (65.6％) ( x2 =4.940,P ＜ 0.05 ).After treatment,the levels of 24h urinary microalbumin and α1-microglobulin were significantly decreased in both groups( t =4.131,3.912,7.253,6.517,all P ＜ 0.05 ).Moreover,the levels of 24h urinary microalbumin and α1-microglobulin in observation group were significantly lower than those in control group( t =5.114,4.526,all P ＜ 0.05 ).Conclusion Tripterygium combined with huangkui capsule in the treatment of diabetic nephropathy could enhance the clinical effects,degrade urinary protein lelves,and had less adverse effect.