The expressions of Sema4D and HER-2 proteins in breast cancers and their clinical significance
10.3760/cma.j.issn.1008-1372.2012.08.003
- VernacularTitle:Sema4D和HER-2在乳腺癌组织中的表达及临床意义
- Author:
Xiaowu XU
;
Xiaomin YANG
;
Yuan XU
;
Shaojun ZHU
;
Pinnan ZHANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms/metabolism;
Receptor,epidermal growth factor;
Semaphorins
- From:
Journal of Chinese Physician
2012;14(8):1017-1021
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of Sema4D and HER-2 in breast cancers and their relationship with microlymphtic vessel density (MLVD).Methods MLVD and expressions of Sema4D and HER-2 were detected in 110 cases of breast cancer tissues by immunohistochemistry.The relationship of Sema4D and HER-2 expressions with clinicopathologic parameters was analyzed.Results The positive expression rate of Sema4D and HER-2 was 71.82％ (79/110) and 33.64％ (37/110),respectively,with a statistically significant differences compared to those in the control group ( P ＜0.01 ).The positive expression rates of Sema4D and MLVD in cases with lymphatic metastasis were higher than that without lymphatic metastasis ( P ＜ 0.01 ).The expressions of Sema4D and HER-2 were closely correlated with the histological grade,TNM stage,lymph node metastasis,and expression of ER of breast cancers ( P ＜0.05),but were not related to tumor size and expression of PR (P ＞ 0.05 ).On univariate analysis,the disease-free survival rate of patients with Sema4D positive expression was better than those with its negative expression ( P ＜ 0.05).Sema4D expression was positively correlated with the HER-2 expression ( r =0.535,P ＜ 0.01 ).Conclusions Sema4D may play important roles in the carcinogenesis and development of a breast cancer.
