The influence of carvedilol on the cardiac function and serum leptin levels in the treatment of patients with diabetic cardiomyopathy

VernacularTitle:卡维地洛对糖尿病心肌病患者左心室功能及血清瘦素水平的影响
Author: Wei ZHONG
Publication Type:Journal Article
Keywords: Cardiomyopathies; Diabetes mellitus; Carvedilol; Leptin; Ventricular function,left; Insulin resistance
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(17):2571-2572
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effects of carvedilol on the cardiac function and serum leptin lever in the treatment of diabetic cardiomyopathy.Methods 40 patients with diabetic cardiomyopathy were randomly divided into carvedilol group and control group.Two groups were given normal therapy and the carvedilol group added carvedilol.The serum levels of leptin and insulin and the heart ultrasound check were measured before and after six months of therapy.Results After therapy the serum levels of leptin and insulin resistance index [ ( 7.18 ± 2.06 ) μg/L,(2.92 ± 0.62) ] were blower than that before therapy in carvedilol group but not control group.After therapy the value of LVEF and E/A were higher[ (46.9 ± 6.8) ％,( 1.05 ± 0.07) ] and LVMI and LVEDd were lower[ ( 108 ± 6 ) g/ m2,(51.8 ± 5.7)mm ] than that before therapy in carvedilol group but not control group( all P ＜ 0.05 ).Conclusion Carvedilol could decrease the levels of serum leptin in patient with diabetic cardiomyopathy and improve insulin resistance and left entricular function.