Nationwide multicentre clinical research on flurbiprofen cataplasm for treating patients with osteoarthritis pain
10.3760/cma.j.issn.1007-7480.2012.09.007
- VernacularTitle:氟比洛芬巴布膏治疗膝骨关节炎疼痛的全国多中心随机 开放 阳性药对照临床研究
- Author:
Hua YE
;
Xiaoxia ZUO
;
Jieruo GU
;
Ping ZHU
;
Hejian ZOU
;
Xiangpei LI
;
Shaoxian HU
;
Zhiyi ZHANG
;
Lingyun SUN
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords:
Flurbiprofen;
Osteoarthritis,knee;
Pain
- From:
Chinese Journal of Rheumatology
2012;16(9):606-610
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect and safety of flurbiprofen cataplasm on osteoarthritis pain in Chinese patients.MethodsOne hundred and eighty-three patients were divided into flurbiprofen cataplasm group,indometacin cataplasm group and Qizheng-xiaotong plaster group randomly.The score of pain,stiffness and physical function were analyzed with WOMAC scale and adverse reactions were also assessed.KruskalWallis H test,Nemenyi test and CMH tese were used.ResultsAfter treatment,the VAS value of the three groups decreased significantly and the VAS difference value of the flurbiprofen cataplasm group changed the most significantly(the changes of VAS value in flat walking,up and down stairs,nighttime,rest and weightbearing were 31±21,35±20,24±19,20±18 and 37±20 respectively).Meanwhile,the value of stiffness and physical function decreased significantly.In terms of safety,flurbiprofen cataplasm group and the indome-tacin cataplasm group were better than Qizheng-xiaotong plaster group.But in sense of constriction,the flurbiprofen cataplasm group was better than the indometacin eataplasm group.ConclusionFlurbiprofen Cataplasm,with its favorable analgesic effect,is suitable for general clinical use.It can reduce stiffness,improvephysical function,and has good safety profile.
