Clinical and serological value of complement C3:a retrospective study of 1405 hospitalized patients with systemic lupus erythematosus
10.3760/cma.j.issn.1007-7480.2012.09.008
- VernacularTitle:系统性红斑狼疮患者补体C3变化及临床意义探讨
- Author:
Fenghong YUAN
;
Lingyun SUN
;
Wenyou PAN
;
Xiangdang WANG
;
Jieping PAN
;
Miaojia ZHANG
;
Yu ZHANG
;
Kuilin TAN
;
Jing LI
;
Zhiwei CHEN
;
Xiang DING
;
Xian QIAN
;
Zhanyun DA
;
Juan TAO
;
Meimei WANG
;
Yaohong ZOU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Retrospective studies;
Complement 3
- From:
Chinese Journal of Rheumatology
2012;16(9):611-615
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the association of complement C3 with clinical and serological features of patients with systemic lupus erythematosus.MethodsData was collected by the same methods in the past ten years in fifteen hospitals in Jiangsu Province and then data weres summarized for retrospective analysis.Clinical and laboratory data were selected and then analyzed by Chi-square test,Wilcoxon rank sum test and Logistic regression.ResultsOne thousand four hundred and five patients were investigated.One thousand and forty two had low serum complement C3 level.In this case control study,hospitalization age,disease course,admission times,pleurisy,gastrointestinal involvement,general lymphadenopathy/hepatosplenomegaly,white blood cell count, haemoglobin level,platelet count, serum C-reactive protein level,serum albumin level,serum creatinine level,Urine protein quantification,anti-nuclear antibodies (ANA),anti-dsDNAantibodies, anti-SmantibodiesandSLEDAIscore were possible factors associatedwith complement C3 reduction(P＜0.05).Logistic regression analysis showed that CRP (OR=0.396,0.254-0.617,P=0.000),ANA (OR=2.907,1.267-6.670,P=0.012),urine protein level(OR=1.702,1.043-2.779,P=0.033) and SLEDAI score (OR-0.930, 0.886-0.975,P-0.003) were correlated with complement C3 reduction.Conclusion Complement C3 level is valuable for lupus flare assessment.The complement C3 reduction is a risk factor for renal impairment.
