The influence of time and dose of mannitol on neural and renal functions in the treatment of hepertensive cerebral hemorrhage
10.3760/cma.j.issn.1008-6706.2012.17.010
- VernacularTitle:甘露醇应用剂量和时间对高血压脑出血患者神经及肾功能的影响
- Author:
Jian YU
;
Hongzun CHEN
;
Zhenhua CUI
- Publication Type:Journal Article
- Keywords:
Mannitol;
Hepertensive cerebral hemorrhage;
Renal function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(17):2579-2580
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of time and dose of mannitol on neural and renal functions in the treatment of hepertensive cerebral hemorrhage.Methods 300 patients with hepertensive cerebral hemorrhage were divided into full-dose group and half-dose group.Full-dose group was divided into group A and group B,and half-dose group was divided into group C and group D.Full-dose group given 20％ mannitol 250ml,and half-dose group was given 20％ mannitol 125ml.Groups A and C were given drug 12h after incerebral hemorrhage occurs,and groups B and D were given drug in the occurrence of cerebral hemorrhage within 12h.The neural and renal functions of every group were compared before the treatment and one week after that.Results The treatment of full-dose group and hulf-dose group was all better,the total effective rate was 71.3％,72.7％,respectively,and there was no significant difference between the two groups ( P ＞ 0.05 ).The total effective rate of groups A,C ( 92.0％,90.7 ％ ) was significantly higher than that of groups B,D (53.3％,50.7％ ) ( all P ＜ 0.05 ).The number of cases [ ( BUN increased more than 7remol/L,61 cases) and(Cr increased more than 133remol/L,64 cases)] in full-dose group was significantly higher than that of half-dose group( 17 cases,17 cases) ( all P ＜ 0.05 ).Conclusion The effect of full-dose and half-dose mannitol in the treatment of hypertensive intracerebral hemorrhage is all better,but renal injury in halfdose mannitol was lower.Giving drug 12h after incerebral hemorrhage occurs is more conducive to hypertensive intracerebral hemorrhage controlled,and could better improve the prognosis.
