The expressions of ER, PR, C-erbB-2, E-Cad, p53 and Ki-67 in breast cancer and their clinical significance

VernacularTitle:ER、PR、C-erbB-2、E-Cad、p53、Ki-67在乳腺癌组织中的表达及意义
Author: Caiyun ZHOU ; Weichun LI
Publication Type:Journal Article
Keywords: Breast tumor; Immunohistochemistry; Receptor; Tumor gene
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(17):2607-2609
CountryChina
Language:Chinese
Abstract: Objective To explore the expressions of ER,PR,C-erbB-2,E-Cad,p53 and Ki-67 in breast cancer and their relationship with clinicopathology.Methods The expressions of ER,PR,C-erbB-2,E-Cad,p53 and Ki-67 proteins were detected in 80 cases of patients with breast cancer using immunohistochemical Streptavidin-Perosidase(SP) method,and were analyzed with clinical and medical records.Results The positive expression rates of ER,PR,C-erbB-2,E-Cad,p53 and Ki-67 in breast cancer were 60.0％,57.5％,45.0％,80.0％,48.8％ and 82.5％,respectively.In addition to C-erbB-2 which had correlation with lymph node metastasis,other five indicators showed no significant correlations with patient age,lymph node metastasis,tumor size and pathological grade.Conclusion There is a certain correlation in the expressions of ER,PR,C-erbB-2,E-Cad,p53 and Ki-67 in breast cancer.Combined detection is valuable in the treatment and prognostic evaluation of breast cancer.