Pyoderma Gangrenosum Treated with Cyclosporine.
- Author:
Kyun Tae KIM
;
Won Soo LEE
;
Eung Ho CHOI
;
Sung Ku AHN
- Publication Type:Case Report
- Keywords:
Cyclosporine;
Pyoderma gangrenosum
- MeSH:
Abdomen;
Blood Urea Nitrogen;
Creatinine;
Cyclosporine*;
Granulation Tissue;
Humans;
Middle Aged;
Prednisolone;
Pyoderma Gangrenosum*;
Pyoderma*;
Recurrence;
Skin;
Thorax;
Ulcer
- From:Korean Journal of Dermatology
1995;33(6):1124-1128
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We present herein a case of pyoderma gangrenosum, which showed good response to cyclosporine therapy. The patient, a 47-year-old man, had suffered from a skin defect on the left anterior chest 2 months before the rapidly spreading pustules and ulcer with an inflammed, irregular undermined border appeared together with a hemorrhagic base which developed on his left anterior chest and upper abdomen. Cyclosporine was given orally in a dose of 150mg three times daily for 2 weeks, and tapering to 100mg three times daily for the next 3 weeks. Clinical improvement was observed after 14 day's treatment and all the skin lesions were replaced by granulation tissue with epithelialization after 35 day's treatment. After the 5-week period of treatment, blood urea nitrogen and creatinine rose to 29 and 1.8 mg/dl. Cyclosporine was stopped and then the patient was given prednisolone (10mg/day) in addition to dapsone(50mg/day) for 1 month. Recurrence has not been observed.
