Wegener' s Granulomatosis.
- Author:
Soo Jung KIM
;
Sang Hoon PARK
;
Kwang Hoon LEE
;
Dong Sik BANG
;
Soo Kon LEE
- Publication Type:Case Report
- Keywords:
Wegener`s granulomatosis;
Necrotizing vasculitis;
ANCA
- MeSH:
Adult;
Antibodies, Antineutrophil Cytoplasmic;
Buttocks;
Congenital Abnormalities;
Cyclophosphamide;
Extremities;
Female;
Glomerulonephritis;
Granuloma;
Humans;
Inflammation;
Kidney;
Lower Extremity;
Lung;
Nasal Cavity;
Nasal Septal Perforation;
Nose;
Prednisolone;
Purpura;
Skin;
Vasculitis;
Wegener Granulomatosis
- From:Korean Journal of Dermatology
1995;33(6):1129-1133
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Wegener's granulomatosis is a systemic necrotizing vasculitis of unknown cause. The disease is characterized by the involvement of the upper airway, the lung, and the kidney. Skin lesions are frequent and the most common lesion is purpura distributed on the limbs and trunk. A 34-year-old female showed recurrent purpuric macules on the both lower extremities and buttocks. The patient. showed nasal septal perforation with saddle nose deformity and C-ANCA positivity. Histopathologic findings of purpuric lesion revealed the features of necrotizing vasculitis. The histologic specimen from the nasal cavity showed chronic inflammation with granuloma formation and kidney showed focal necrotizing glomerulonephritis. Therefore, we treated the patient with prednisolone and cyclophosphamide having diagnosed Wegener's granulomatosis.
