Level of plasma D-dimer in the patients of type 2 diabetes mellitus with hypertension
10.3760/cma.j.issn.1008-6315.2012.10.005
- VernacularTitle:2型糖尿病合并高血压患者血清D-二聚体的表达
- Author:
Lu CUI
;
Rui LI
;
Xiulan GAO
;
Youxia CHEN
;
Guiyan CHEN
;
Chao CHEN
;
Xinjun WANG
;
Shuze XIA
;
Feng WEI
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Hypertension;
D-dimer
- From:
Clinical Medicine of China
2012;28(10):1022-1024
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the plasma D-dimer level in the patients of type 2 diabetes mellitus with hypertension and investigate their correlation.Methods Eighty-five subjects were divided into three groups according to clinical manifestation:control group:20 subjects ; type 2 diabetes mellitus group:21 subjects; type 2 diabetes mellitus combined with hypertension group:44 subjects.The level of plasma D-dimer was measured and the difference was compared between groups.The results were showed as mean ± sd,and the difference was compared using ANOVA Test ( SPSS13.0).Results The plasma D-dimer concentrations in normal control group was ( 102.15 ± 32.48 ) μg/L,in single type 2 diabetes mellitus was ( 148.62 ± 80.99 ) μg/L,while plasma concentrations in type 2 diabetes mellitus combined with hypertension was ( 206.28 ± 92.99 ) μg/L.plasma D-dimer concentration was higher in single type 2 diabetes mellitus than that in normal control cases( P ＜0.05) ;And plasma D-dimer concentration was also found increased in type 2 diabetes mellitus combined with hypertension when compared with control group (P ＜ 0.01 ) ;And there was also significant difference on plasma D-dimer concentration between single type 2 diabetes mellitus and type 2 diabetes mellitus combined with hypertension cases ( P ＜ 0.05 ).Conclusion The plasma levels of D-dimer was increased obviously in single type 2 diabetes mellitus and type 2 diabetes mellitus combined with hypertension,it may be related to the imbalance of coagulation and fibrinolytic system.Monitoring of plasma D-dimer concentration in type 2 diabetes and patients with hypertension may have important clinical implications for the prevention of thrombotic diseases.
