Effect research of aliskiren on bradykinin and high sensitive C-reactive protein in hypertension patients
10.3760/cma.j.issn.1673-4904.2012.30.009
- VernacularTitle:阿利吉仑对高血压患者缓激肽和高敏C反应蛋白的影响研究
- Author:
Fengyi GUO
;
Zhenhong HUO
;
Yulian SHEN
;
Dayan ZHANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Bradykinin;
C-reactive proteins;
Aliskiren
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(30):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of a novel non-peptide renin inhibitor aliskiren on hypertension patients,and analyze the change of bradykinin (BK) and high sensitive C-reactive protein (hs-CRP).MethodsEighty patients with mild to moderate hypertension were selected.Patients were randomized divided into ramipril group,aliskiren 75 mg/d group,aliskiren 150 mg/d group,aliskiren 300 mg/d group with 20 cases each by random digits table method and received the following types of intervention:ramipril 5 mg/d,aliskiren 75 mg/d,aliskiren 150 mg/d and aliskiren 300 mg/d.Enzyme-linked immunosorbent assay method was used for detecting hs-CRP.Radioimmunoassay method was used for detecting BK.Results After treatment,the levels of BK and hs-CRP in aliskiren 75 mg/d group,aliskiren 150 mg/d group and aliskiren 300 mg/d group [(5.06 ± 1.61),(5.05 ± 1.87),(5.27 ± 1.39) μg/L and (0.38 ± 0.11 ),(0.25 ± 0.05),(0.33 ± 0.11 ) mg/L] were significantly lower than those in ramipril group [ (7.12 ± 1.12) μ g/L,(0.49 ± 0.19) mg/L ] (P＜0.05 ).After treatment,the levels of SBP and DBP had no significant difference among the four groups (P＞0.05).Conclusion Aliskiren has a very good effect in decreasing blood pressure and does not cause the levels of BK and hs-CRP increasing.
